Author's response to reviews Title: Brain metastases from breast cancer: prognostic significance of HER-2 overexpression, effect of trastuzumab and cause of death Authors:

Beta1-integrin circumvents the antiproliferative effects of trastuzumab in human epidermal growth factor receptor-2-positive breast cancer.

Resistance to trastuzumab, the monoclonal antibody targeting human epidermal growth factor receptor 2 (HER-2), is a major concern for HER-2-positive metastatic breast cancer (MBC) patients. To date, HER-2 status is the only available biomarker for selecting patients for trastuzumab-based therapy. Beta(1)-integrin, an adhesion molecule involved in cell survival and drug resistance, shares common...

Her-2 overexpression increases the metastatic outgrowth of breast cancer cells in the brain.

Retrospective studies of breast cancer patients suggest that primary tumor Her-2 overexpression or trastuzumab therapy is associated with a devastating complication: the development of central nervous system (brain) metastases. Herein, we present Her-2 expression trends from resected human brain metastases and data from an experimental brain metastasis assay, both indicative of a functional con...

Author's response to reviews Title: Distinct distribution and prognostic significance of molecular subtypes of breast cancer in Chinese women: a population-based cohort study Authors:

Targeting HER2 in brain metastases from breast cancer.

For many types of cancers, therapy aimed at a specific molecular target remains in the realm of clinical research. However, for breast cancer, rational therapeutics is routinely practiced in the clinic. For many years, oncologists have used tamoxifen to selectively treat women with estrogen receptorpositive breast cancer. Clinicians now screen breast cancer for HER2 overexpression, which occurs...

تحلیل بقای بیماران مبتلا به سرطان پستان با در نظر گرفتن پیشامدهای میانی و پایانی: کاربرد مدل بیماری- مرگ

Background and Objectives: Breast cancer is the leading cause of death from cancer among women. In developing countries, the patients’ survival is less than developed countries. Metastasis, as an intermediate event, affects the survival of breast cancer patients. This study aimed to evaluate the survival of patients after surgery considering metastasis, as the intermediate event, using the illn...